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Each state creates its own regulations, and products can vary a lot. The researchers say many medications are poorly labeled with misleading information about chemical contents.
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“We need these consistent formulations,” said RTI scientist Brian Thomas. “So that we can have product standards and quality control to assure we can manufacture them again and again in a re-producable fashion.”
Ryan Vandrey from the Johns Hopkins School of Medicine spoke at an RTI webinar Thursday along with Thomas. He conducted a study measuring the drugs for THC, the main chemical in many medical marijuana products. Most products deviated from the marketed THC amount by more than 10 percent.
Mislabeled products not only mislead the customer, they can pose a health risk. Overdosing on marijuana typically isn’t associated with a high risk of death, but it often leads to anxiety, paranoia, hallucinations, cardiac stress or cognitive impairment.
RTI researcher Scott Novak conducted a study showing more than 65 percent of cannabis users have overdosed in their lifetimes, which suggests to him that there’s a lot of bad labeling and patients are using trial and error to find the right product. This is why you should always get your cbd from the right source, click here for your pure CBD Oil.
“They are in a real search in terms of trying to figure out the appropriate dose and formulation that lines up with a way to sub-medicate their symptoms,” Novak said.
Vandrey spoke about another need for standardization – the delivery methods. Specifically, he said edible cannabis should be standardized into one food source.
“There’s no basis in medicine anywhere else for putting medicine inside a brownie, a cupcake, popcorn, sodas and gummy bears,” Vandrey said.
Vandrey said the multiple food sources available now can confuse both the consumer and analytics. That’s because test results for drug potency vary between foods.
Another issue with edible cannabis is its slow absorption. If a patient consumes a mislabeled product, it could take hours before it’s known if he or she overdosed or needs more.
Taylor West, deputy director of the National Cannabis Industry Association, said individuals respond to different products so limiting the types of food sources for edibles could be unnecessary.
“I’m not really sure I see the rationale for putting severe limitations on the actual form of the product unless you can show that there’s some legitimate harm to doing it that way,” West said.
Marijuana’s medicinal uses can be traced back as early as 2737 B.C., when the emperor of China, Shen Neng, touted cannabis tea as a treatment for gout, rheumatism, malaria and even poor memory, writes Mitch Earleywine, a professor of psychology at the State University of New York at Albany who researches drugs and addiction, in “Understanding Marijuana: A New Look at the Scientific Evidence” (Oxford University Press, 2005). The drug’s popularity as a medicine spread throughout Asia, the Middle East and then to Africa and India, where Hindu sects used it for pain and stress relief.
William O’Shaughnessy, an Irish doctor, popularized medical use of cannabis in England and America after noting its effects in India.
Researchers at the American Academy of Neurology have also found that medical marijuana in the form of cbd oil, pills or oral sprays seemed to reduce stiffness and muscle spasms in multiple sclerosis (MS). The medications also eased certain symptoms of MS, such as pain related to spasms, and painful burning and numbness, as well as overactive bladder, according to a number of studies.
A well-known effect of marijuana use is the “munchies,” so it has been used to stimulate appetite among HIV/AIDS patients and others who have a suppressed appetite due to a medical condition or treatment. Medical marijuana is also frequently used to treat nausea induced by chemotherapy, though scientific studies of the smoked form of the plant are limited.
“You do not need a randomized, placebo-controlled trial to tell you that cannabis is effective as an antinausea therapy for patients getting chemotherapy,” Abrams said. “It works. It’s like needing to do a placebo-controlled trial of penicillin as an antibiotic.”
Two FDA-approved, chemically altered forms of THC, dronabinol and nabilone, have been shown to reduce chemotherapy-related nausea and vomiting in cancer patients. It is also used to help with the symptoms of AIDS, according to the U.S. National Library of Medicine.
Medical marijuana has also been touted as a treatment for glaucoma, which is an elevated pressure in the eyeball that can lead to blindness. While smoking marijuana may reduce intraocular pressure, marijuana must be consumed numerous times during the day to have the desired effect and other drugs are more effective, according to the American Cancer Society. Cannabidiol (CBD) is a non-psychoactive component of marijuana that has therapeutic benefits, but because it does not target the CB1 receptor, it doesn’t leave people feeling stoned.
For example, a 2012 study published in the journal Translational Psychiatry found that cannabidiol may be effective in treating schizophrenia. In the study at the University of Cologne, 42 patients randomly received either cannabidiol or amisulpride, an effective drug used for the treatment of schizophrenia, for 28 days. Comparison of the clinical effects found “no relevant difference” between the two treatments.
A 2014 study by the College of Pharmacy of the University of South Florida that THC could be helpful in the therapeutic treatment of Alzheimer’s disease, as well.
Medical Marijuana Side Effects
Marijuana does have side effects. THC binds to cannabinoid receptors, which are concentrated in areas of the brain associated with thinking, memory, pleasure, coordination and time perception. The effects of marijuana can interfere with attention, judgment and balance.
Studies have produced conflicting results on whether smoking marijuana carries a significant cancer risk. Medical marijuana “prescriptions” are termed “recommendations” or “referrals” because of federal laws prohibiting the prescribing of cannabis.
A 2016 study on 108 people by the University of Michigan Health System found that marijuana use may also make other addictions worse.
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